EuroClonality is a European scientifically independent foundation aiming to promote continuous innovation and standardization of laboratory diagnostics in hemato-oncology with a special emphasis on clonality testing and supporting quality control and education in laboratory diagnostics. EuroClonality developed and standardized novel multiplex PCR assays for detection of immunoglobulin (IG) and T-cell receptor (TR) gene rearrangements. These assays are now widely used for the diagnosis of lymphoproliferative disorders.Read more about EuroClonality
About the EuroClonality-NGS Working Group
The EuroClonality-NGS Working Group is a working group of EuroClonality that aims to research and set standards in IG/TR NGS methodology and its applications in hemato-oncology, hematology and immunology.Read more about the EuroClonality-NGS Working Group
EuroClonality EQA Scheme
Together with the Biomedical Quality Assurance Research Unit of the KU Leuven, EuroClonality organizes an annual External Quality Assessment scheme. All laboratories working with the EuroClonality/BIOMED-2 multiplex PCR assays for detection of IG/TR gene rearrangements can join this EQA scheme to evaluate their performance.Read more about the EuroClonality EQA Scheme
EuroClonality Educational Workshops
Each year, the EuroClonality Educational Workshop “Clonality Assessment in Pathology” is organized in Nijmegen, The Netherlands. This workshop addresses questions on pitfalls in technique and interpretation of the results of the EuroClonality/BIOMED-2 multiplex PCR assays.Read more about the EuroClonality Educational Workshops
Support and Protocols
EuroClonality and the EuroClonality-NGS Working Group also offer support to the diagnostic community via the Online Diagnostic Support Service for problematic cases in clonality testing with the EuroClonality/BIOMED-2 assays, a FAQ section on the use of these assays, and by providing protocols of IG/TR NGS methodology.
Workshop 2022 is postponed
Due to COVID measures, the EuroClonality Educational Workshop “Clonality assessment in Pathology” is postponed and will take place on 9-11 May 2022 in Nijmegen, The Netherlands.
New EuroClonality-NGS Working Group publications
Publications on validation of NGS-based clonality assessment of Ig gene rearrangements and the EuroClonality-NGS DNA capture panel as an integrated genomic tool for lymphoproliferative disorders (available from Univ8, Belfast, UK) are out in the Journal of Molecular Diagnostics and Blood Advances.
New EuroClonality publication on 1-tube TRG assays
EuroClonality evaluated the performance of the new EuroClonality TRG 1-tube assay and the TRG2.0 assay (Invivoscribe, San Diego, US) in a multi-center study.