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About EuroClonality

EuroClonality is a European scientifically independent foundation aiming to promote continuous innovation and standardization of laboratory diagnostics in hemato-oncology with a special emphasis on clonality testing and supporting quality control and education in laboratory diagnostics. EuroClonality developed and standardized novel multiplex PCR assays for detection of immunoglobulin (IG) and T-cell receptor (TR) gene rearrangements. These assays are now widely used for the diagnosis of lymphoproliferative disorders.

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About the EuroClonality-NGS Working Group

The EuroClonality-NGS Working Group is a working group of EuroClonality that aims to research and set standards in IG/TR NGS methodology and its applications in hemato-oncology, hematology and immunology.

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EuroClonality EQA Scheme

Together with the Biomedical Quality Assurance Research Unit of the KU Leuven, EuroClonality organizes an annual External Quality Assessment scheme. All laboratories working with the EuroClonality/BIOMED-2 multiplex PCR assays for detection of IG/TR gene rearrangements can join this EQA scheme to evaluate their performance.

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EuroClonality Educational Workshops

Each year, the EuroClonality Educational Workshop “Clonality Assessment in Pathology” is organized in Nijmegen, The Netherlands. This workshop addresses questions on pitfalls in technique and interpretation of the results of the EuroClonality/BIOMED-2 multiplex PCR assays.

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Support and Protocols

EuroClonality and the EuroClonality-NGS Working Group also offer support to the diagnostic community via the Online Diagnostic Support Service for problematic cases in clonality testing with the EuroClonality/BIOMED-2 assays, a FAQ section on the use of these assays, and by providing protocols of IG/TR NGS methodology.

EHA scientific working group logo

ESLHO, together with the independent scientific foundations EuroFlow, EuroClonality and EuroMRD, is an official EHA Scientific Working Group (SWG).

New Methods in Molecular Biology volume on Immunogenetics

The book contains 27 chapters on methods and protocols used in the immunogenetics field, many of them contributed by the EuroClonality-NGS Working Group. The full volume is open access.

Access all chapters here

EuroClonality-NGS DNA Capture assay

Following publication of the EuroClonality-NGS DNA capture assay, this integrated genomic tool for lymphoproliferative disorders is now available from Univ8 Genomics (Belfast, UK): www.univ8genomics.com/euroclonality-ndc

Blood Advances publication on the EuroClonality-NDC assay

New EuroClonality publication on 1-tube TRG assays

EuroClonality evaluated the performance of the new EuroClonality TRG 1-tube assay and the TRG2.0 assay (Invivoscribe, San Diego, US) in a multi-center study.

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