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About EuroClonality

EuroClonality is a European scientifically independent foundation aiming to promote continuous innovation and standardization of laboratory diagnostics in hemato-oncology with a special emphasis on clonality testing and supporting quality control and education in laboratory diagnostics. EuroClonality developed and standardized novel multiplex PCR assays for detection of immunoglobulin (IG) and T-cell receptor (TR) gene rearrangements. These assays are now widely used for the diagnosis of lymphoproliferative disorders.

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About the EuroClonality-NGS Working Group

The EuroClonality-NGS Working Group is a working group of EuroClonality that aims to research and set standards in IG/TR NGS methodology and its applications in hemato-oncology, hematology and immunology.

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Diagnostic innovations by EuroClonality

Since the start of the collaboration in 1996, the EuroClonality Consortium has developed, optimized, standardized and validated various new assays and related tools to improve diagnostic patient care.

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EuroClonality EQA Scheme

Together with the Biomedical Quality Assurance Research Unit of the KU Leuven, EuroClonality organizes an annual External Quality Assessment scheme. All laboratories working with the EuroClonality/BIOMED-2 multiplex PCR assays for detection of IG/TR gene rearrangements can join this EQA scheme to evaluate their performance.

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EuroClonality Educational Workshops

Each year, the EuroClonality Educational Workshop “Clonality Assessment in Pathology” is organized in Nijmegen, The Netherlands. This workshop addresses questions on pitfalls in technique and interpretation of the results of the EuroClonality/BIOMED-2 multiplex PCR assays.

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Support and Protocols

EuroClonality and the EuroClonality-NGS Working Group also offer support to the diagnostic community via the Online Diagnostic Support Service for problematic cases in clonality testing with the EuroClonality/BIOMED-2 assays, a FAQ section on the use of these assays, and by providing protocols of IG/TR NGS methodology.

EHA specialized working group logo

ESLHO, together with the independent scientific foundations EuroFlow, EuroClonality and EuroMRD, is an official EHA Specialized Working Group (SWG).

Open ESLHO Symposium on November 7th in Lisbon

ESLHO organizes the 13th ESLHO Symposium on the 7th of November in LIsbon, Portugal. At the Convento do Beato, renowned speakers from the ESLHO Consortia, EuroFlow, EuroClonality and EuroMRD will share their knowledge on Multi-omics approaches for diagnosis and monitoring of hematological malignancies.

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EuroClonality publishes Recommendations for Evaluation of B-Cell Clonality Analysis by Next-Generation Sequencing.

NGS-based clonality analysis is a powerful technique for the assessment of Ig clonality, but it has its specific pitfalls. EuroClonality developed a step-by-step approach to interpretation of NGS-amplicon–based assessment of clonality which will allow a reliable and reproducible interpretation of the results and will help to avoid overinterpretation. This is all published in a paper named: EuroClonality-NGS Recommendations for Evaluation of B-Cell Clonality Analysis by Next-Generation Sequencing: A Structured Approach with the DEPART Algorithm.

Find the paper in EuroClonality publications

New Methods in Molecular Biology volume on Immunogenetics

The book contains 27 chapters on methods and protocols used in the immunogenetics field, many of them contributed by the EuroClonality-NGS Working Group. The full volume is open access.

Access all chapters here