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About EuroClonality

EuroClonality is a European scientifically independent foundation aiming to promote continuous innovation and standardization of laboratory diagnostics in hemato-oncology with a special emphasis on clonality testing and supporting quality control and education in laboratory diagnostics. EuroClonality developed and standardized novel multiplex PCR assays for detection of immunoglobulin (IG) and T-cell receptor (TR) gene rearrangements. These assays are now widely used for the diagnosis of lymphoproliferative disorders.

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About the EuroClonality-NGS Working Group

The EuroClonality-NGS Working Group is a working group of EuroClonality that aims to research and set standards in IG/TR NGS methodology and its applications in hemato-oncology, hematology and immunology.

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EuroClonality EQA Scheme

Together with the Biomedical Quality Assurance Research Unit of the KU Leuven, EuroClonality organizes an annual External Quality Assessment scheme. All laboratories working with the EuroClonality/BIOMED-2 multiplex PCR assays for detection of IG/TR gene rearrangements can join this EQA scheme to evaluate their performance.

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EuroClonality Educational Workshops

Each year, the EuroClonality Educational Workshop “Clonality Assessment in Pathology” is organized in Nijmegen, The Netherlands. This workshop addresses questions on pitfalls in technique and interpretation of the results of the EuroClonality/BIOMED-2 multiplex PCR assays.

Read more about the EuroClonality Educational Workshops

Support and Protocols

EuroClonality and the EuroClonality-NGS Working Group also offer support to the diagnostic community via the Online Diagnostic Support Service for problematic cases in clonality testing with the EuroClonality/BIOMED-2 assays, a FAQ section on the use of these assays, and by providing protocols of IG/TR NGS methodology.

EHA scientific working group logo

ESLHO, together with the independent scientific foundations EuroFlow, EuroClonality and EuroMRD, is an official EHA Scientific Working Group (SWG).

Registration for EuroClonality EQA scheme 2023 open

The External Quality Assessment scheme for IG/TR Clonality Testing in Suspected Lymphoproliferations/Lymphoma is organized under ISO 17043 accreditation by the Biomedical Quality Assurance Research Unit of KU Leuven together with EuroClonality. Note that this year, wet cases can be analyzed by any technique, including amplicon or capture based NGS. Registration will be possible until 17 February 2023.

Information and registration for the EQA 2023

New publication on NGS capture-based somatic hypermutation status assessment

In a combined effort, several participants of the EuroClonality-NGS Working Group tested a novel next-generation sequencing capture-based strategy to report somatic hypermutation status using genomic regions downstream to immunoglobulin rearrangements. The resulting publication was accepted in December 2022 in Haematologica.

Go to EuroClonality publications

New Methods in Molecular Biology volume on Immunogenetics

The book contains 27 chapters on methods and protocols used in the immunogenetics field, many of them contributed by the EuroClonality-NGS Working Group. The full volume is open access.

Access all chapters here